The identification of neural substrates underlying the long lasting debilitating impact of drug cues is critical for developing novel therapeutic tools. Metabolic coupling has long been considered a key mechanism through which astrocytes and neurons actively interact in response of neuronal activity, but recent findings suggested that disrupting metabolic coupling may represent an innovative approach to prevent memory formation, in particular drug‐related memories. Here, we review converging evidence illustrating how memory and addiction share neural circuitry and molecular mechanisms implicating lactate‐mediated (...) metabolic coupling between astrocytes and neurons. With several aspects of addiction depending on mnemonic processes elicited by drug experience, disrupting lactate transport involved in the formation of a pathological learning, linking the incentive, and motivational effects of drugs with drug‐conditioned stimuli represent a promising approach to encourage abstinence. (shrink)

The Theodotian Susanna has been studied by various scholars in various ways. Each attempt to give some meaning to this narrative has a different emphasis from a text, context or receiver based angle. This paper presents a mixture of text and context based angles. It focuses on the different spaces in Theodotian Susanna, that is, the house, garden, court and finally heaven. Each of these spaces is contested, but there can only be one victor.

This article aims to present a brief historical overview of interpretative theories and methods relevant to those books that are included in either the Protestant Apocrypha or the Catholic Deuterocanonical in the LXX (Septuagint) for the period 1891–2020. The aim of the article is not to give a complete description of all research on apocryphal/deuterocanonical books. The author’s journey with the relevant literature commenced in 2006, when he was appointed as one of the translators of apocryphal texts for a new (...) edition of the new Afrikaans Bible (2020). Initially, he felt trapped as if in a maze. However, as his research progressed and as he met and talked to LXX experts at that stage, the road began to seem less of an obstacle and more like a challenge. One of the important aspects that he discovered was that not every text in the LXX has a so-called Hebrew Vorlage. Although the author describes different approaches used to interpret LXX material, for example historical-grammatical methods, his focus is on South African LXX research that has made a unique contribution to the previous and existing research, especially by the researchers of the North-West University. Contribution: The article briefly discusses several researchers who have made unique contributions to the LXX apocryphal/deuterocanonical research during the last decade. These scholars utilised different methods to interpret the LXX texts – methods that were not previously employed regularly if at all, for example narratology and narrative theory, cognitive linguistics, cultural anthropology, semiotic theory, rhetorical theory and performance theory. (shrink)

La 4e de couverture indique :"Nous n'avons rien à apprendre des idiots, c'est évident! D'ailleurs, ne sommes-nous pas de plus en plus intelligents, malins, calculateurs, performants? En tout état de cause une chose est certaine : malheur à ceux qui ne le sont pas. Dans ce paysage, la figure de l'idiot n'est même plus interrogée, elle est purement et simplement effacée, confondue avec celle de l'imbécile, de l'abruti, du demeuré... Pourtant, lorsque Pierre J. Truchot s'arrête, et... nous arrête, sur (...) le personnage remarquable de l'Idiot, nous reconnaissons des visages rares, mais familiers. Des figures croisées au cours de notre existence. Des sourires d'une audacieuse franchise, des paroles étranges à force de sincérité, des accoutrements vestimentaires qui affirment l'incontournable singularité du goßt, des oeuvres poétiques, picturales, musicales, généreuses et désarmantes. Oui, assurément, à une époque où certains, frustrés par les limites de l'être humain nous promettent déjà des prothèses, implants et autres nanoaugmentateurs d'humanité, l'idiot continue à s'émerveiller d'une fleur ou du bruissement d'un ruisseau, trouve encore le temps de parler aux enfants, devine la tristesse ou partage les joies de ses interlocuteurs, rit sans méchanceté (pour lui c'est possible) de nos illusions rationnelles. Oui, assurément, l'Idiot n'a rien à nous apprendre.". (shrink)

L'oubli est précédé par sa mauvaise réputation. Pensé comme un manque de la mémoire, le symptôme d'une dégénérescence annoncée, on le redoute. On cherche à l'oublier bien que l'on sache qu'il sera toujours là. Pourtant, s'il ne faisait pas quotidiennement son œuvre, on ne pourrait plus vivre, agir ou créer. Oublier est une faculté universelle et vitale dont les modalités d'expression diffèrent de celles de la mémoire : une puissance enfouie en notre être, une force créatrice capable de nous régénérer. (...) À contre-courant des modes et humeurs de notre société, des philosophes, des anthropologues et surtout des artistes n'ont pas oublié d'oublier tous les fardeaux qui se présentent comme des obstacles à leur désir de création. Développer sa capacité à effacer les évènements pesants et traumatisants qui nous conduisent au désastre est moins un risque qu'un pari, dont l'enjeu est de rendre à chaque personne ce qu'elle désire peut-être le plus au monde : affirmer sa réelle singularité, notamment par et dans l'acte créatif."--Page 4 of cover. (shrink)

Globalisation develops at a staggering pace that envelopes and infiltrates local South African communities in various ways. Through technology a person can have access to anything today. Should the church try to keep up, or compete with such a reality? This article aims to encourage the church to develop a responsible missional character, which embraces the opportunities globalisation offers – to be a participative forum in a community comprising of more than religious people. Through re-evaluating the church’s missional intent, by (...) shifting the paradigm away from self-centred outcomes, the church should contribute to such a community’s articulation of faith. (shrink)

The view of the deity and the people in 2 Maccabees seems to be a dynamic rather than a stagnant relationship. On the one hand, the deity sometimes punishes his people through the enemy. However, in other instances, he defends them against the same enemy. In this sequence of events, the ‘Heliodorus scene’ in 2 Maccabees 3 is quite unique. A protagonist and his helpers (a man on a horse and two youths) as well as an antagonist and his helpers (...) (Heliodorus and his bodyguard) can be shown. Minor, seemingly insignificant players – the ‘widows and orphans’ – are also found. Doran states that mentioning them in this scene is possibly a rhetorical ploy and refers to LXX Psalms 67:6 (Ps 68:5) as possible background. However, Doran, unfortunately, does not investigate LXX Psalms 67 further. Upon closer inquiry, this text might show an interesting context for the Heliodorus scene and the making of the people. It demonstrates how ‘the people’ should conduct themselves, the role of the sanctuary, and if one can expect the deity to get involved. Contribution: This is a new contribution as the relationship between LXX Psalms 67 and 2 Maccabees 3 has never been looked at in this way. (shrink)

This article addresses the highly disputed distribution of roles in the story of Susanna. Susanna consists of a number of actors of whom only a few such as Susanna, the two elders, the Jewish people and Daniel are directly related to the central action of the story. With regard to the roles of these actors in the story however, a question arises: Who is the subject of the story of Susanna? Most scholars question the attribution of the role of subject (...) to Susanna. Their contention however, has not yet been sustained by convincing evidence stemming from the use of a suitable method. This study attempts to fill this gap by using the Greimassian approach to narratives, as refined by Everaert-Desmedt. The approach comprises three levels of analysis: the figurative, the narrative and the thematic. The contribution focuses only on the narrative level of analysis, particularly on the actantial model because the main role of this structure is to reveal different functions of actors called here actants. It is the contention here that following the actantial model of the Greimassian approach of analysis, Susanna emerges as the subject of the main concern of the story. (shrink)

This article deals with a highly debated text, namely 2 Maccabees 12, specifically the problematic verses (38–45) which contain a theology that is distinctly non-Jewish in import. Indeed, most recent scholars concerned with this passage do not seem to be unanimous apropos the best interpretation of the events that are described, resulting in a range of different opinions concerning, inter alia, the afterlife, purgatory and/or doctrinal disputes between Pharisees and Sadducees. By means of an interpretivist or constructivist epistemology, the authors (...) advocate that normally, traditional Judaism emphasises personal, individual responsibility and accountability, whereas in this text God is portrayed as requiring material, financial payment for wrongdoing and not individual תשובה [teshuvah]. This is in contradistinction to, inter alia, Exodus 30:11–16 and theologically Jewish ‘transgression’ has clearly metamorphosed into Christian ‘sin’. In addition, Judas Maccabeus seems to have retained a half-shekel methodology (employed for Jewish men of military age – soldiers) whilst emphasising the ‘atonement for your lives’ from Exodus 30:11–16 in a more literalistic, materialistic, non-Jewish sense whilst de-emphasising the real need to maintain the Temple as well as the proper, traditional rules of תשובה. (shrink)

Given the strong mimetic and dramatic qualities found in Judith the authors make the suggestion that perhaps, before LXX Judith became a fixed, written text, the basic fabula might well have been part of an oral tradition. The authors accept that an appropriately written dramatic work, whether transmitted through reading or an oral presentation, by means of its performative qualities, has the potential to achieve immediacy. Here, the audience may become captivated with its own familiarity and memory of popular, communally (...) shared narratives. Accordingly, this article attempts to find evidence in the Greek text of LXX Judith for a possible oral precursor. In this context, corroboration is sought for the employment of verbal aspect and mood of the Greek language as well as instances of drama, theatrics, bodily gestures, mnemonic devices or special emphasis on the employment of the senses such as sight, taste and smell. The authors suggest that based on an analysis of the text of Chapter 13, there is much circumstantial evidence for the Judith fabula once being an oral narrative – one that embodies the dramatic and even encourages audience participation. This characteristic strongly suggests the removal of the fourth wall – the notion of an imaginary boundary between any fictional work and its audience. Contribution: This article shows that Judith 13 is indeed the climax of the narrative. However, it goes further. It is a vivid scene with various performative aspects. There are props, dialogue and audience participation. This research is cutting-edge and paves the way for new explorations. (shrink)

The Septuagint Book of Judith and its derivatives have had an enormous influence on the history of Western Europe and the Christian church. Judith has been employed in various situations to incite violence against a perceived opposition. In this regard, this article focuses on the climax of this book (Jdt 13:1–9) as performance text. In this context, many of the insights proffered by Perry in his seminal work Insights from Performance Criticism (2016) have been expanded upon from the perspective of (...) a Greek and/or Hellenistic environment.Contribution: The value of reading LXXJudith as performance is clearly demonstrated. The conclusion is reached that this pericope is indeed highly subversive. Suggestion is also made that, contrary to more conservative wisdom, with reference specifically to LXXJudith 13:1–9, the Judith fabula is not really reconciliatory in nature. Rather, it seems to provoke conflict between competing powers. (shrink)

The emerging field of neuroeducation, concerned with the interaction between mind, brain and education, has proved revolutionary in educational research, introducing concepts, methods, and technologies into many advanced institutions around the world. The Educated Brain presents a broad overview of the major topics in this new discipline: Part I examines the historical and epistemological issues related to the mind/brain problem and the scope of neuroeducation; Part II provides a view of basic brain research in education and use of imaging techniques, (...) and the study of brain and cognitive development; and Part III is dedicated to the neural foundations of language and reading in different cultures, and the acquisition of basic mathematical concepts. With contributions from leading researchers in the field, this book features the most recent and advanced research in cognitive neurosciences. (shrink)

The present work is aimed at investigating the effects of myocardial infarction and ischemia on induction of ventricular fibrillation. Electrophysiologic effects of global and local ischemia (variation of the dispersion of refractory periods as well as conduction velocity) on initiation of reentry mechanisms was studied by means of computer simulations based on a cellular automata model of propagation of activation wave through a ventricular surface element. A local area of ischemia where effects of the dispersion of refractory periods are investigated (...) is then simulated. This is made using a Gaussian distribution characterized by its mean and standard deviation. These simulations show that ischemia is capable of initiating reentry phenomena which propagate through the whole ventricle; they are responsible for ventricular fibrillation which causes sudden cardiac death, even when ischemia only involves limited parts of the myocardium. Statistical study of the probability of reentries as a function of both of the size of ischemic zones and the rate of dispersion of refractory periods shows that the latter parameter is of primary importance in triggering cardiac reentries. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

This article aims to clarify the epistemological foundations of the Freudian energetics model, starting with a historical review of the 19th century scientific context in which Freud's research lay down its roots. Beyond the physiological and anatomical references of Project for a Scientific Psychology, the physiology Freud makes reference to is in reality primarily anchored in an epistemological model derived from physics. Whilst across the Rhine, the autonomy of physiology in relation to physics was far from being accomplished, as a (...) counterpoint, in France, the revolution in physiology driven by Claude Bernard established itself autonomously from physics,. In contrast, Freud's scientific landscape is entirely dominated by the physics elevated to the rank of an ideal science. The influence of Helmholtz, who is both a medical doctor and a physicist, has a determining influence on Freud's training. The discoveries in physics at that time, in particular the formulation of the principle of 'conservation of force' - first principle of thermodynamics - will constitute the points of reference upon which Freud will elaborate his energetics model, then subsequently, the idea of economy in his metapsychology. In this way we can trace both the historic and epistemological path that led Freud from a concept based on physics, and more specifically thermodynamic energy, to an idea of nervous energy that constitutes the basis of the concept of "quantity" as it is stated as 'first fundamental idea' in Project for a Scientific Psychology. This notion will subsequently evolve, and lead Freud to the introduction of the concept of 'psychical energy,' this time in a purely metapsychological sense. (shrink)

Through the contributions of specialists in the field, this volume addresses the still open question of the role and status of myth in Plato’s dialogues and thereby speaks to the broader problem of the relation between philosophy and ...